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KMID : 0525720000050020065
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Journal of Chitin and Chitosan
2000 Volume.5 No. 2 p.65 ~ p.69
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Chemopreventive Potential of Chitosan Oligosaccharides
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남미영/Nam MY
손윤희/김세권/정특래/남경수/Shon YH/Kim SK/Jeong TR/Nam KS
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Abstract
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Chitosan Oligosaccharides (COS), COS I (M.W.: 3,000~5,000 daltons) and COS H (M.W. : 1,000~3,000daltons), were tested for their chernopreventive potentials using three biochemical markers of carcinogenesissuch as quinone reductase, glutathione S-transferase and glutathione. COS I and COS H were potent inducers of quinone reductase activity in murine hepatoma cells (Hepalclc7). Glutathione S-transferase activity was increased about 1.5 fold with COS Ⅱ in cultured murine hepatoma cells. In addition glutathione levels were slightly increased with COS Ⅰ. These results suggest that Chitosan Oligosaccharides has a chernopreuentive potential by inducing quinone reductase and glutathione S-transferase activities and increasing glutathione levels.
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KEYWORD
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